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We strive to learn something new every day and want to share it with you. Read on to see what inspires us.

New York Academy of Sciences - October 28, 2018

We are proud to announce our participation in the New York Academy of Sciences meeting on New Strategies to Combat Antimicrobial Resistance.  Our first product—coming out later this year—will address one of the leading indications for antibiotic prescriptions—cough and cold.  Antibiotics are among the most important medical breakthroughs.  However, they also pressure bacteria to evolve resistance and become more dangerous.

Applied Biological Laboratories has developed all natural, anti-viral formulations that effectively treat and prevent respiratory infections in an entirely new way.  They treat viruses while antibiotics do not, but they also strengthen the fragile respiratory barrier and prevent secondary antibacterial infections for which antibiotics are often prescribed.  These approaches are not likely to lead to anti-microbial resistance because they don’t threaten or pressure viruses, they simply shield our respiratory cells from them.  

A paper published in PLOS Biology by Kristofer Waldentoft and Sam Brown at Georgia Tech argue that new antimicrobials should act locally rather than systemically, act specifically rather than broadly, and that they should not disturb the microbiome.  Applied Biological Laboratories products adhere to all of these tenets.

If use of these products become wide-spread, the frequency and spread of upper respiratory tract infections will decrease as will the need for antibiotics, an equally important medical necessity. 

 

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The Air We Breathe - October 24, 2018

We go to great lengths to keep the harmful pathogens in our environment out of our bodies. While we may wash our hands, and avoid touching a subway pole, we can’t stop breathing. We need to breathe about 20 times a minute and with each breathe, we risk inhaling any number of undesirable microscopic particles floating around in the air. Luckily, our airway epithelial cells (the cells lining our mouth, nose, throat, and lungs) are there to defend us. These cells have various chemical signals at their disposal to deactivate harmful pathogens right away and if necessary signal a stronger immune response. Dr. Iwasaki and colleagues at Yale did a great job of explaining the communication between airway epithelial cells and the rest of the immune system. More importantly, in this paper, they identify ways in which our airway defenses may be compromised such as by cigarette smoking, obesity, cool temperatures, and certain metabolic or hormonal conditions.

   
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Lowering the Temperature of Respiratory Cells - October 24, 2018

Wow mothers really do know best. My mom always made me wear a scarf. Now that I am studying these viruses in the lab, we lower the temperature of respiratory cells (below body temperature) to help cold viruses grow so we can study them.
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